Cognitive decline in middle age may not result from b-amyloid deposition, according to a study published online ahead of print March 16 in JAMA Neurology. Declines in memory and hippocampal volume
occur at earlier ages than abnormal amyloid PET does,
which implies that these outcomes “must have some
mechanistic independence from b-amyloid accumulation,” said Clifford R. Jack Jr., MD, Professor of Radiology at Mayo Clinic in Rochester, Minnesota.
From age 70 onward, median amyloid PET accumu-
lation is greater in cognitively normal individuals with
the APOE ε4 allele, compared with people without the
allele. In addition, abnormal amyloid PET may appear
at an earlier age among APOE ε4 carriers, compared
with noncarriers. The study results also indicate that
male gender, but not APOE ε4, is associated with worse
memory and adjusted hippocampal volume among cog-
nitively normal individuals.
A Population Between Ages 30 and 95
Dr. Jack and colleagues conducted a cross-sectional observational study from March 2006 to October 2014
to compare the effects of age, sex, and APOE ε4 on
memory, brain structure (ie, adjusted hippocampal volume), and amyloid PET in cognitively normal people.
The researchers studied 1,246 participants from two
cohorts. The first cohort was a random sample of 1,209
Does Amyloid Accumulation
Cause Midlife Cognitive Decline?
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